Comparison of four homologous retention index standard series for qualitative gas chromatography of nitrogenous acidic and neutral drugs

Four homologous retention index standard series, the alkylmethylhydantoins, alkylhydantoins, alkylmaleimides and alkylbis(trifluoromethyl)phosphine sulphides, were evaluated for the screening of blood samples for acidic and neutral drugs on Ultra 2 and HP-1701 capillary columns over a six-month peri...

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Bibliographic Details
Published in:Journal of Chromatography A 1996-07, Vol.738 (2), p.233-239
Main Authors: Rasanen, Ilpo, Ojanperä, Ilkka, Vuori, Erkki, Hase, Tapio A.
Format: Article
Language:English
Subjects:
Alkylbis(trifluoromethyl)phosphine sulphides
Alkylhydantoins
Alkylmaleimides
Alkylmethylhydantoins
Blood Chemical Analysis
Capillary gas chromatography
Chromatography, Gas - methods
Drug screening
Drugs
Humans
Hydrogen-Ion Concentration
Pharmaceutical Preparations - analysis
Retention indices
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Summary:Four homologous retention index standard series, the alkylmethylhydantoins, alkylhydantoins, alkylmaleimides and alkylbis(trifluoromethyl)phosphine sulphides, were evaluated for the screening of blood samples for acidic and neutral drugs on Ultra 2 and HP-1701 capillary columns over a six-month period. An index series consisting of actual drug substances was used as a standard of comparison. All the series produced high precision, and the precision differences between the series were rather small. Considering the limitations of the other series, the alkylmethylhydantoins and alkylhydantoins turned out to be the most feasible internal retention index standard series in the present dual column setting.
ISSN:0021-9673
DOI:10.1016/0021-9673(96)00095-7