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Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice

The alymphoplasia (aly) mutation of mice causes the systemic absence of lymph nodes, Peyer's patches and well-defined lymphoid follicles in the spleen. We found that antibody responses are elicited, albelt weakly, to either T cell-dependent or T cell-Independent antigen by aly/aly mutants. Howe...

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Published in:	International immunology 1996-07, Vol.8 (7), p.1067-1075
Main Authors:	Shinkura, Reiko, Matsuda, Fumihiko, Sakiyama, Toshio, Tsubata, Takeshi, Hial, Hiroshi, Paumen, Michael, Miyawaki, Shigeki, Honjo, Tasuku
Format:	Article
Language:	English
Subjects:	aly/aly mice Amino Acid Sequence Animals Antibody Formation - genetics Antibody Specificity Antigens, T-Independent - physiology Base Sequence Genetic Variation - genetics Genetic Variation - immunology Germinal Center - pathology immune response Immunoglobulin Class Switching Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - pathology Lymph Nodes - abnormalities Lymphoid Tissue - abnormalities Mice Mice, Mutant Strains Molecular Sequence Data Mutation - immunology Peyer's Patches - abnormalities somatic hypermutation Spleen - abnormalities
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container_title	International immunology
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creator	Shinkura, Reiko Matsuda, Fumihiko Sakiyama, Toshio Tsubata, Takeshi Hial, Hiroshi Paumen, Michael Miyawaki, Shigeki Honjo, Tasuku
description	The alymphoplasia (aly) mutation of mice causes the systemic absence of lymph nodes, Peyer's patches and well-defined lymphoid follicles in the spleen. We found that antibody responses are elicited, albelt weakly, to either T cell-dependent or T cell-Independent antigen by aly/aly mutants. However, isotype switching was defective. The T cell-dependent immune response was not elicited in splenectomized aly/aly mice. Neither hypermutation nor germinal center formation was observed in aly/aly mice. These results suggest that T–B collaboration requires either lymph nodes or spleen, and that hypermutation and affinity maturation depend on germinal center formation.
doi_str_mv	10.1093/intimm/8.7.1067
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source	Oxford Journals Online
subjects	aly/aly mice Amino Acid Sequence Animals Antibody Formation - genetics Antibody Specificity Antigens, T-Independent - physiology Base Sequence Genetic Variation - genetics Genetic Variation - immunology Germinal Center - pathology immune response Immunoglobulin Class Switching Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - pathology Lymph Nodes - abnormalities Lymphoid Tissue - abnormalities Mice Mice, Mutant Strains Molecular Sequence Data Mutation - immunology Peyer's Patches - abnormalities somatic hypermutation Spleen - abnormalities
title	Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice
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