Endothelium-Dependent and Endothelium Independent Vasodilation in Resistance Arteries from Hypertensive Rats

The endothelium-dependent and presumed endothelium-independent vasodilators acetylcholine and sodium nitroprusside, respectively, were used to characterize relaxation responses of mesenteric resistance arteries from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto rats (WKY). Ve...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1988-05, Vol.11 (5), p.440-444
Main Authors: TESFAMARIAM, BELAY, HALPERN, WILLIAM
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Endothelium, Vascular - physiopathology
Experimental diseases
Hypertension - physiopathology
Medical sciences
Mesenteric Arteries - physiopathology
Nitroprusside - pharmacology
Norepinephrine - pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Serotonin - pharmacology
Vascular Resistance - drug effects
Vasoconstriction - drug effects
Vasodilation
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Summary:The endothelium-dependent and presumed endothelium-independent vasodilators acetylcholine and sodium nitroprusside, respectively, were used to characterize relaxation responses of mesenteric resistance arteries from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto rats (WKY). Vessels were preconstricted using concentrations of norepinephrine or 5-hydroxytryptamine, which reduced then-diameters by 50 to 60%. Relaxation responses to acetylcholine (10-10 M) were significantly smaller (p < 0.05) hi vessel segments from SHRSP, but the maximal relaxations at higher concentrations were the same in both strains. However, SHRSP vessels relaxed to a greater extent than did those of the WKY at all concentrations of sodium nitroprusside. Endothelium removal significantly enhanced sodium nitroprusside–induced dilations in both rat strains, and the dilations were significantly greater in segments from SHRSP in the concentration range of 3 × 10 to 10 M. The decreased relaxation to acetylcholine hi resistance arteries from adult hypertensive rats compared with those from the normotensive strain suggests that functional alterations hi the endothelium may play a role in hypertensive disease.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.11.5.440