Effects of Some Psychotropic Drugs on the b-Wave of the Electroretinogram in Isolated Rabbit Retina

The role of dopaminergic and cholinergic functions in the genesis of an electroretinogram is unclear. The present study was carried out to elucidate the direct actions of some psychotropic drugs in isolated rabbit retinas. Methamphet-amine and apomorphine decreased dose-dependently the b-wave amplit...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1988, Vol.46 (1), p.97-100
Main Authors: NAKAGAWA, Terutake, KURASAKI, Sigeru, MASUDA, Tiharu, UKAI, Kiyoharu, KUBO, Satoko, KADONO, Hirosi
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Electroretinography
Eye
In Vitro Techniques
Male
Medical sciences
Pharmacology. Drug treatments
Psychotropic Drugs - pharmacology
Rabbits
Retina - drug effects
Retina - physiology
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Summary:The role of dopaminergic and cholinergic functions in the genesis of an electroretinogram is unclear. The present study was carried out to elucidate the direct actions of some psychotropic drugs in isolated rabbit retinas. Methamphet-amine and apomorphine decreased dose-dependently the b-wave amplitude at a dose of 10-7–10-5 g/ml. On the other hand, chlorpromazine and haloperidol, as well as atropine and amitriptyline, increased dose-dependently the b-wave amplitude at the same dose range. These data support the idea that dopaminergic and cholinergic systems play an important role in the genesis of the ERG.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)43358-1