Phosphoinositide-generated messengers in cardiac signal transduction

A multitude of agonists like e.g. endothelin-1, angiotensin-II, serotonin, thrombin, histamine and vasopressin as well as alpha 1-adrenergic and muscarinic stimulation lead to stimulation of the phosphoinositide cycle in the heart. Besides the seven membrane spanning-domain receptor-coupled stimulat...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1996-04, Vol.157 (1-2), p.5-14
Main Authors: van Heugten, H A, Eskildsen-Helmond, Y E, de Jonge, H W, Bezstarosti, K, Lamers, J M
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - pharmacology
Angiotensin II - pharmacology
Animals
Cholinergic Agents - pharmacology
Endothelins - pharmacology
Growth Substances - physiology
GTP-Binding Proteins - metabolism
Heart - drug effects
Heart - physiology
Histamine - pharmacology
Humans
Inositol Phosphates - metabolism
Isoenzymes - metabolism
Myocardium - metabolism
Phosphatidylinositols - metabolism
Phospholipase C beta
Second Messenger Systems
Serotonin - pharmacology
Signal Transduction
Thrombin - pharmacology
Type C Phospholipases - metabolism
Vasopressins - pharmacology
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Summary:A multitude of agonists like e.g. endothelin-1, angiotensin-II, serotonin, thrombin, histamine and vasopressin as well as alpha 1-adrenergic and muscarinic stimulation lead to stimulation of the phosphoinositide cycle in the heart. Besides the seven membrane spanning-domain receptor-coupled stimulation of the key enzyme of the phosphoinositide cycle, phospholipase C-beta, another class of hormones, growth factors, also couple to the phosphoinositide cycle, now through receptors with intrinsic tyrosine kinase activity that can phosphorylate and stimulate the phospholipase C-gamma isozyme. In this review we summarize the multitude of receptor (sub)types, G-protein-subunit- and phospholipase C-isozymes that are present in the heart. Furthermore, generation of second messengers and cellular responses are described together with the (patho)physiological implications for the heart of phosphoinositide cycle activation and second messenger accumulation.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00227875