Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2

Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induce...

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Published in:Science (American Association for the Advancement of Science) 1996-08, Vol.273 (5275), p.645-647
Main Authors: Yokoi, Mineto, Kobayashi, Katsunori, Manabe, Toshiya, Takahashi, Tomoyuki, Sakaguchi, Isako, Katsuura, Goro, Shigemoto, Ryuichi, Ohishi, Hitoshi, Nomura, Sakashi, Nakamura, Kenji, Nakao, Kazuki, Katsuki, Motoya, Nakanishi, Shigetada
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Biological and medical sciences
Cell lines
Central nervous system
Cyclopropanes - pharmacology
Depression (Psychology)
Electric Stimulation
Electrophysiology
Exons
Fundamental and applied biological sciences. Psychology
Gene Targeting
Genetics
Glycine - analogs & derivatives
Glycine - pharmacology
Hippocampus (Brain)
Hippocampus - cytology
Hippocampus - physiology
In Vitro Techniques
Inhibition
Logical Thinking
Long term depression
Long term potentiation
Maze Learning
Mazes
Mice
Mice, Knockout
Mutation
Neural transmission
Neuronal Plasticity
Neurons
Pyramidal Cells - physiology
Quadrants
Receptors, Metabotropic Glutamate - genetics
Receptors, Metabotropic Glutamate - physiology
Receptors, N-Methyl-D-Aspartate - physiology
Rodents
Stem cells
Synapses
Synapses - drug effects
Synapses - physiology
Synaptic transmission
Synaptic Transmission - drug effects
Vertebrates: nervous system and sense organs
Water
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Summary:Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.273.5275.645