Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2

Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induce...

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Published in:Science (American Association for the Advancement of Science) 1996-08, Vol.273 (5275), p.645-647
Main Authors: Yokoi, Mineto, Kobayashi, Katsunori, Manabe, Toshiya, Takahashi, Tomoyuki, Sakaguchi, Isako, Katsuura, Goro, Shigemoto, Ryuichi, Ohishi, Hitoshi, Nomura, Sakashi, Nakamura, Kenji, Nakao, Kazuki, Katsuki, Motoya, Nakanishi, Shigetada
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Biological and medical sciences
Cell lines
Central nervous system
Cyclopropanes - pharmacology
Depression (Psychology)
Electric Stimulation
Electrophysiology
Exons
Fundamental and applied biological sciences. Psychology
Gene Targeting
Genetics
Glycine - analogs & derivatives
Glycine - pharmacology
Hippocampus (Brain)
Hippocampus - cytology
Hippocampus - physiology
In Vitro Techniques
Inhibition
Logical Thinking
Long term depression
Long term potentiation
Maze Learning
Mazes
Mice
Mice, Knockout
Mutation
Neural transmission
Neuronal Plasticity
Neurons
Pyramidal Cells - physiology
Quadrants
Receptors, Metabotropic Glutamate - genetics
Receptors, Metabotropic Glutamate - physiology
Receptors, N-Methyl-D-Aspartate - physiology
Rodents
Stem cells
Synapses
Synapses - drug effects
Synapses - physiology
Synaptic transmission
Synaptic Transmission - drug effects
Vertebrates: nervous system and sense organs
Water
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cited_by cdi_FETCH-LOGICAL-c782t-34b7984eb9a13705693c82cdeaad344a913de57e800144bba3624f317275ee913
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container_title Science (American Association for the Advancement of Science)
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creator Yokoi, Mineto
Kobayashi, Katsunori
Manabe, Toshiya
Takahashi, Tomoyuki
Sakaguchi, Isako
Katsuura, Goro
Shigemoto, Ryuichi
Ohishi, Hitoshi
Nomura, Sakashi
Nakamura, Kenji
Nakao, Kazuki
Katsuki, Motoya
Nakanishi, Shigetada
description Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.
doi_str_mv 10.1126/science.273.5275.645
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Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8662555</pmid><doi>10.1126/science.273.5275.645</doi><tpages>3</tpages></addata></record>
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identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1996-08, Vol.273 (5275), p.645-647
issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_78218239
source American Association for the Advancement of Science; JSTOR Archival Journals and Primary Sources Collection; ProQuest Social Science Premium Collection; Education Collection
subjects Animals
Axons - physiology
Biological and medical sciences
Cell lines
Central nervous system
Cyclopropanes - pharmacology
Depression (Psychology)
Electric Stimulation
Electrophysiology
Exons
Fundamental and applied biological sciences. Psychology
Gene Targeting
Genetics
Glycine - analogs & derivatives
Glycine - pharmacology
Hippocampus (Brain)
Hippocampus - cytology
Hippocampus - physiology
In Vitro Techniques
Inhibition
Logical Thinking
Long term depression
Long term potentiation
Maze Learning
Mazes
Mice
Mice, Knockout
Mutation
Neural transmission
Neuronal Plasticity
Neurons
Pyramidal Cells - physiology
Quadrants
Receptors, Metabotropic Glutamate - genetics
Receptors, Metabotropic Glutamate - physiology
Receptors, N-Methyl-D-Aspartate - physiology
Rodents
Stem cells
Synapses
Synapses - drug effects
Synapses - physiology
Synaptic transmission
Synaptic Transmission - drug effects
Vertebrates: nervous system and sense organs
Water
title Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2
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