Hair iron content: possible marker to complement monitoring therapy of iron deficiency in patients with chronic inflammatory bowel diseases?

Measurements of the concentration of iron in hair from 10 patients with chronic inflammatory bowel diseases and from 10 healthy controls showed that the iron concentrations were significantly (P < 0.05) lower in patients before iron intake than in controls. Three weeks after beginning iron treatm...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 1996-08, Vol.42 (8), p.1270-1274
Main Authors: Bisse, E, Renner, F, Sussmann, S, Scholmerich, J, Wieland, H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers
Chronic Disease
Colitis, Ulcerative - complications
Crohn Disease - complications
Ferritins - blood
Gastroenterology. Liver. Pancreas. Abdomen
Hair - chemistry
Hair - metabolism
Humans
Inflammatory Bowel Diseases - complications
Iron - analysis
Iron - deficiency
Iron - therapeutic use
Kinetics
Medical sciences
Other diseases. Semiology
Reticulocyte Count
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Transferrin - metabolism
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Summary:Measurements of the concentration of iron in hair from 10 patients with chronic inflammatory bowel diseases and from 10 healthy controls showed that the iron concentrations were significantly (P < 0.05) lower in patients before iron intake than in controls. Three weeks after beginning iron treatment, the hair iron concentrations were found to be significantly correlated (r = 0.68; P < 0.05) to reticulocyte counts. Changes in the hair iron concentrations were accompanied by similar changes in the concentrations of the markers most commonly used to diagnose and monitor iron deficiency. The results suggest that quantification of hair iron may be useful to complement evaluations of the body iron status.
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/42.8.1270