Not all Shc's roads lead to Ras

The Shc proteins have been implicated in the Ras signaling pathway by virtue of their association with the Grb2 adaptor molecule. Several lines of evidence indicate that this association is indeed involved in Ras activation. More recent experiments in mammalian tissue culture cells suggest that doma...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 1996-07, Vol.21 (7), p.257-261
Main Authors: Bonfini, Laura, Migliaccio, Enrica, Pelicci, Giuliana, Lanfrancone, Luisa, Pelicci, PierGiuseppe
Format: Article
Language:English
Subjects:
Animals
Phosphorylation
Proteins - metabolism
ras Proteins - metabolism
Receptor Protein-Tyrosine Kinases - metabolism
Receptor, Epidermal Growth Factor - metabolism
Signal Transduction - physiology
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Summary:The Shc proteins have been implicated in the Ras signaling pathway by virtue of their association with the Grb2 adaptor molecule. Several lines of evidence indicate that this association is indeed involved in Ras activation. More recent experiments in mammalian tissue culture cells suggest that domains unique to Shc isoforms, named CH1 and CH2, might be involved in a new network of protein-protein interactions, and hint at other roles that Shc might play in addition to Ras activation.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(96)10033-5