A STUDY ON CEFTRIAXONE IN THE PERINATAL PERIOD

Ceftriaxone (CTRX), a new cephem antibiotic with high activity against Grampositive and Gramnegative bacteria, was investigated pharmacokinetically in 30 mothers in the perinatal period. The obtained results are summarized below. 1. The maximum CTRX level in the maternal serum was 135 μg/ml between...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1988/02/25, Vol.41(2), pp.210-215
Main Authors: TAKASE, ZENJIRO, FUJIWARA, MICHIHISA, MIYOSHI, TOSHIHIRO, NAKAYAMA, MASATO, KOHMOTO, YOSHIYUKI, SHIRAFUJI, HIROKO
Format: Article
Language:Japanese
Subjects:
Abortion, Induced
Amniotic Fluid - metabolism
Ceftriaxone - administration & dosage
Ceftriaxone - pharmacokinetics
Ceftriaxone - therapeutic use
Endometritis - drug therapy
Endometritis - prevention & control
Female
Fetal Blood - metabolism
Fetal Membranes, Premature Rupture - drug therapy
Humans
Injections, Intravenous
Pregnancy
Puerperal Infection - drug therapy
Puerperal Infection - prevention & control
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Summary:Ceftriaxone (CTRX), a new cephem antibiotic with high activity against Grampositive and Gramnegative bacteria, was investigated pharmacokinetically in 30 mothers in the perinatal period. The obtained results are summarized below. 1. The maximum CTRX level in the maternal serum was 135 μg/ml between 20 and 25 minutes after an intravenous administration of 1g of CTRX. 2. The transfer of CTRX into the umbilical cord serum and the amniotic fluid was very good. CTRX levels in these fluids were about 20% and 10% of the maternal serum level, respectively. 3. No side effect was observed in mothers or neonates. 4. CTRX is a useful antibiotic for perinatal infections.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.41.210