Long-term positron emission tomography evaluation of slowly progressive gliomas

Non-invasive positron emission tomography (PET) was performed to identify changes in blood flow and metabolism, specific to early stages of tumour occurrence or recurrence. 2 patients with slowly progressive gliomas from early to late stages of tumour development were analysed by serial PET measurem...

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Bibliographic Details
Published in:European journal of cancer (1990) 1996-06, Vol.32 (7), p.1257-1260
Main Authors: Mineura, K., Sasajima, T., Kowada, M., Ogawa, T., Hatazawa, J., Uemura, K.
Format: Article
Language:English
Subjects:
18F-fluorodeoxyglucose
Adult
Biological and medical sciences
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - metabolism
Disease Progression
early diagnosis
Female
Follow-Up Studies
Glioma - diagnostic imaging
Glioma - metabolism
gliomas
glucose metabolism
Humans
Medical sciences
Neurology
Oxygen Consumption
oxygen extraction fraction
oxygen metabolism
positron emission tomography (PET)
Tomography, Emission-Computed
Tomography, X-Ray Computed
Tumors of the nervous system. Phacomatoses
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Summary:Non-invasive positron emission tomography (PET) was performed to identify changes in blood flow and metabolism, specific to early stages of tumour occurrence or recurrence. 2 patients with slowly progressive gliomas from early to late stages of tumour development were analysed by serial PET measurements of circulation and metabolism using 15O-gas and 18F-fluorodeoxyglucose. PET revealed a persistent depression of oxygen metabolism, as indicated by the regional oxygen extraction fraction or metabolic rate of oxygen, in the regions where tumours were later found. Abnormal blood flow and metabolism may precede the morphological changes detected by computed tomography (CT) in patients with gliomas.
ISSN:0959-8049
1879-0852
DOI:10.1016/0959-8049(96)00026-3