FADE PROFILES DURING SPONTANEOUS OFFSET OF NEUROMUSCULAR BLOCKADE: VECURONIUM AND GALLAMINE COMPARED

The characteristics of the train-of-four (TOF) response have been studied electromyographically during the onset and the spontaneous offset of neuromuscular blockade indued with vecuronium or gallamine. During the onset of blockade, at 75% depression of initial twitch height, gallamine was associate...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1988-04, Vol.60 (5), p.486-490
Main Authors: POWER, S.J., PEARCE, A.C., JONES, R.M.
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Cholinesterase Inhibitors - pharmacology
Female
Gallamine Triethiodide - antagonists & inhibitors
Gallamine Triethiodide - pharmacology
Humans
Male
Medical sciences
Middle Aged
Muscle Contraction - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Time Factors
Ulnar Nerve - physiology
Vecuronium Bromide - antagonists & inhibitors
Vecuronium Bromide - pharmacology
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Summary:The characteristics of the train-of-four (TOF) response have been studied electromyographically during the onset and the spontaneous offset of neuromuscular blockade indued with vecuronium or gallamine. During the onset of blockade, at 75% depression of initial twitch height, gallamine was associated with significantly more TOF fade than vecuronium. Both agents were associated with significantly less fade during onset than during spontaneous offset. When the two neuromuscular blocking drugs were compared during spontaneous offset they showed a similar degree of fade during early offset (up to 50% recovery of initial twitch height). However, during late spontaneous offset, when the initial twitch height had recovered to 75% of control values, vecuronium was associated with more fade than gallamine.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/60.5.486