Sensitivity of Left Ventricular End-Systolic Pressure-Volume Relation to Type of Loading Intervention in Dogs

The influence of different types of loading intervention on the resulting end-systolic pressure-volume relation (ESPVR) of the left ventricle in situ was investigated in anesthetized open-chest dogs. Left ventricular volume was measured by conductance catheter and pressure was measured by tip-micro-...

Full description

Saved in:
Bibliographic Details
Published in:Circulation research 1988-06, Vol.62 (6), p.1247-1258
Main Authors: Baan, Jan, Van Der Velde, Enno T
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Circulation
Blood Pressure
Blood Volume
Cardiology. Vascular system
Cardiopulmonary Bypass
Dogs
Heart
Heart - physiology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Medical sciences
Systole
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The influence of different types of loading intervention on the resulting end-systolic pressure-volume relation (ESPVR) of the left ventricle in situ was investigated in anesthetized open-chest dogs. Left ventricular volume was measured by conductance catheter and pressure was measured by tip-micro-manometer. Two loading interventions were applieda pressure intervention (INp) by gradually occluding the descending aorta and a volume intervention (INv) by rapidly infusing 180 ml blood into the vena cava. The pressure-volume loops during an intervention always showed a linear ESPVR, the slope of which, Ees, was calculated. Possible method-related artifacts were assessed and could be excluded. Results from 16 dogs show that Ees(INp) was always larger (1.37 ± 0.45 kPa/ml) than Ees(INv) (0.73 ± 0.32 kPa/ml) (p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.62.6.1247