Atriopeptin III Induces Early Relaxation of Isolated Mammalian Papillary Muscle

Atrial natriuretic peptide, released by mammalian atria in response to volume overload, induces vasodilation and natriuresis. In this study, a direct effect on cardiac mechanical performance was demonstrated. Atriopeptin III (10-10 M) induced early relaxation and decreased peak twitch of isometric a...

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Bibliographic Details
Published in:Circulation research 1988-06, Vol.62 (6), p.1171-1174
Main Authors: Meulemans, A L, Sipido, K R, Sys, S U, Brutsaert, D L
Format: Article
Language:English
Subjects:
Animals
Atrial Natriuretic Factor - pharmacology
Biological and medical sciences
Dibutyryl Cyclic GMP - pharmacology
Dose-Response Relationship, Drug
Endocardium - pathology
Endocardium - physiopathology
Fundamental and applied biological sciences. Psychology
Heart
In Vitro Techniques
Myocardial Contraction - drug effects
Nitroprusside - pharmacology
Papillary Muscles - drug effects
Time Factors
Vertebrates: cardiovascular system
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Summary:Atrial natriuretic peptide, released by mammalian atria in response to volume overload, induces vasodilation and natriuresis. In this study, a direct effect on cardiac mechanical performance was demonstrated. Atriopeptin III (10-10 M) induced early relaxation and decreased peak twitch of isometric and isotonic twitches of isolated papillary muscles of cat and rat, without affecting maximal unloaded velocity of shortening. This effect resembled the effects of dibutyryl cyclic GMP and of sodium nitroprusside on cardiac muscle. The action of atriopeptin III, but not of dibutyryl cyclic GMP or sodium nitroprusside, was abolished by mechanically or chemically damaging the endocardial endothelial surface. Thus, the early relaxation of cardiac muscle induced by atrial natriuretic peptide may be mediated through receptors on the endocardial endothelium.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.62.6.1171