Long-term Effects of Parathyroidectomy on Cardiac and Autonomic Nervous System Functions in Haemodialysis Patients

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 1988, Vol.3 (1), p.45-50
• Main Authors: Zucchelli, P., Santoro, A., Zucchelli, A., Spongano, M., Ferrari, G.
• Format: Article
• Language: English
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Autonomic nervous system; Autonomic Nervous System - physiology; Biological and medical sciences; Blood Pressure; Cardiac function; Echocardiography; Emergency and intensive care: renal failure. Dialysis management; Female; Heart Rate; Hemodynamics; Humans; Hyperparathyroidism, Secondary - etiology; Hyperparathyroidism, Secondary - physiopathology; Hyperparathyroidism, Secondary - surgery; Intensive care medicine; Male; Medical sciences; Middle Aged; Parathyroid Glands - surgery; Parathyroid Hormone - blood; Parathyroidectomy; Renal Dialysis - adverse effects; Uraemia; Uremia - physiopathology; Uremia - therapy; Valsalva Maneuver
• ISSN: 0931-0509; 1460-2385; 1460-2385
• DOI: 10.1093/oxfordjournals.ndt.a091618

Ten patients receiving regular haemodialysis therapy who underwent parathyroidectomy for secondary hyperparathyroidism were investigated to evaluate the effects of parathyroid hormone on left ventricular and autonomic nervous system functions. The study which included M-mode echocardiography and autonomic nervous system tests (hormonal and cardiovascular response to the postural test, cold pressor test, handgrip test, diving reflex test and Valsalva manoeuvre) were performed prior to parathyroidectomy, and 5–8 months after, on a non-dialysis day. The cardiovascular response and plasma noradrenaline changes to postural test remained unchanged following parathyroidectomy. The resting heart rate decreased from 73.1±2.4 to 66.4±2.3 beats/min (P