DMSO-induced changes in the procoagulant and fibrinolytic activity of B16 melanoma cells: influence on lung colony formation

In this study DMSO (dimethylsulphoxide) was used as a tool to test the significance of in vitro modifications of procoagulant and fibrinolytic activity of tumor cells for their in vivo metastatic ability. B16 melanoma cells were chosen as the experimental model. After four days' treatment DMSO...

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Bibliographic Details
Published in:Clinical & experimental metastasis 1988-09, Vol.6 (5), p.377-385
Main Authors: Casali, B, Lampugnani, M G, Riganti, M, Niewiarowska, A, Alessio, G, Mussoni, L, Semeraro, N, Donati, M B
Format: Article
Language:English
Subjects:
Animals
Blood Coagulation - drug effects
Cell Line - drug effects
Cysteine Endopeptidases - analysis
Dimethyl Sulfoxide - pharmacology
Fibrinolysis - drug effects
Lung Neoplasms - secondary
Melanoma - physiopathology
Mice
Neoplasm Proteins
Plasminogen Activators - analysis
Thromboplastin - analysis
Tumor Cells, Cultured - drug effects
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Summary:In this study DMSO (dimethylsulphoxide) was used as a tool to test the significance of in vitro modifications of procoagulant and fibrinolytic activity of tumor cells for their in vivo metastatic ability. B16 melanoma cells were chosen as the experimental model. After four days' treatment DMSO increased both the procoagulant and fibrinolytic (plasminogen activator) activity of B16 melanoma cells in a dose-related manner. DMSO treated cells showed significantly greater lung colonizing ability than untreated cells. Our results indicate that DMSO treatment in vitro can modulate procoagulant and fibrinolytic activity and the metastatic ability of B16 melanoma cells; however a direct causal relationship between these in vitro and in vivo effects remains to be established.
ISSN:0262-0898
1573-7276
DOI:10.1007/BF01760573