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Analysis of Leukotriene Receptor Antagonists on Isolated Human Intralobar Airways

Results from functional as well as radioligand binding studies have provided evidence for the existence of subtypes of receptors for leukotrienes in several mammalian tissues. The suggestion that leukotriene C sub(4) (LTC sub(4)) and leukotriene D sub(4) (LTD sub(4)) cause contraction of guinea-pig...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1988, Vol.524 (1), p.181-186
Main Authors: BUCKNER, C. K., SABAN, R., CASTLEMAN, W. L., WILL, J. A.
Format: Article
Language:English
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Summary:Results from functional as well as radioligand binding studies have provided evidence for the existence of subtypes of receptors for leukotrienes in several mammalian tissues. The suggestion that leukotriene C sub(4) (LTC sub(4)) and leukotriene D sub(4) (LTD sub(4)) cause contraction of guinea-pig airways by interacting with different receptor subtypes was based on observations that FPL55712, a leukotriene receptor antagonist, was less potent in antagonizing responses to the former agonist. This report summarizes the authors' studies with human airways using leukotriene receptor antagonists.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1988.tb38540.x