Macrophage-like cells in muscularis externa of mouse small intestine: immunohistochemical localization of F4/80, M1/70, and Ia-antigen

Macrophage-like cells (MLC) in mouse small intestine are situated in the muscularis externa in the subserosal layer at the level of Auerbach's plexus, and at the level of the deep muscular plexus. By combined labelling with FITC-dextran and immunohistochemical techniques, the MLC were shown to...

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Bibliographic Details
Published in:Cell and tissue research 1988-05, Vol.252 (2), p.301-306
Main Authors: MIKKELSEN, H. B, MIRSKY, R, JESSEN, K. R, THUNEBERG, L
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - analysis
Antigens, Differentiation - analysis
Biological and medical sciences
Cell coat. Cell surface
Cell structures and functions
Dextrans
Female
Fluorescein-5-isothiocyanate - analogs & derivatives
Fluoresceins
Fluorescent Antibody Technique
Fundamental and applied biological sciences. Psychology
Histocompatibility Antigens Class II - analysis
Immunohistochemistry
Intestine, Small - cytology
Intestine, Small - immunology
Macrophages - cytology
Macrophages - immunology
Mice
Mice, Inbred BALB C
Molecular and cellular biology
Muramidase - analysis
Muramidase - immunology
Muscles - cytology
Muscles - immunology
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Summary:Macrophage-like cells (MLC) in mouse small intestine are situated in the muscularis externa in the subserosal layer at the level of Auerbach's plexus, and at the level of the deep muscular plexus. By combined labelling with FITC-dextran and immunohistochemical techniques, the MLC were shown to express the macrophage markers F4/80 and M1/70.15. The MLC appeared to be constitutively IE-antigen-positive, but did not contain lysozyme. It is suggested that MLC, like Langerhans cells, belong to a specialized class of cells in the mononuclear phagocyte system.
ISSN:0302-766X
1432-0878
DOI:10.1007/bf00214372