Inactivated Marburg virus elicits a nonprotective immune response in Rhesus monkeys

In the present work the kinetics of some indices of immunity (tumor necrosis factor (TNF), interferon (IFN), natural killer cells (NK), lymphocyte proliferation activity, virus-specific antibodies, CD4/CD8 ratio) in response to Marburg virus infection in Macaca mulatta were studied. The different ki...

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Bibliographic Details
Published in:Journal of biotechnology 1996-01, Vol.44 (1), p.111-118
Main Authors: Ignatyev, George M., Agafonov, Alexander P., Streltsova, Marina A., Kashentseva, Elena A.
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Antibodies, Viral - biosynthesis
Antibodies, Viral - blood
Antibody Formation
Biotechnology
CD4-CD8 Ratio
Guinea Pigs
Immune response
Interferons - biosynthesis
Killer Cells, Natural - immunology
Kinetics
Lymphocyte Activation
Lymphocyte proliferation
Macaca mulatta
Marburg virus
Marburg Virus Disease - immunology
Marburg Virus Disease - prevention & control
Marburgvirus - immunology
Mediator of immunity
Time Factors
Tumor Necrosis Factor-alpha - biosynthesis
Vaccines, Inactivated
Viral Vaccines
Virus antibody
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Summary:In the present work the kinetics of some indices of immunity (tumor necrosis factor (TNF), interferon (IFN), natural killer cells (NK), lymphocyte proliferation activity, virus-specific antibodies, CD4/CD8 ratio) in response to Marburg virus infection in Macaca mulatta were studied. The different kinetics of immunological parameters for animals which survived Marburg virus infection and for animals which died after infection are shown. A comparison of the indices of IFN, TNF and spontaneous lymphocyte proliferation activity in Macaca mulatta infected with Marburg virus at different stages of life shows the relationship between the increase of these indices and the decrease in the animals' lifespan. Marburg virus immunosuppressive properties were corroborated by studying lymphocyte proliferation activity in response to antigenic stimulation in vitro and the CD4/CD8 index during experimental Marburg virus infection in Macaca mulatta. We conclude that the disease outcome depends on the dynamics of certain immunologie indices such as TNF and IFN.
ISSN:0168-1656
1873-4863
DOI:10.1016/0168-1656(95)00104-2