Age-related changes in rat liver plasma membrane sphingomyelinase activity

• Published in: Experimental gerontology 1988, Vol.23 (1), p.19-24
• Main Authors: Petkova, Diana H., Momchilova-Pankova, Albena B., Markovska, Tania T., Koumanov, Kamen S.
• Format: Article
• Language: English
• Subjects: aging; Aging - metabolism; Animals; Biological and medical sciences; Cell Membrane - metabolism; Development. Metamorphosis. Moult. Ageing; Fundamental and applied biological sciences. Psychology; Liver - metabolism; Male; Membrane Lipids - metabolism; phosphatidylcholine; Phosphatidylcholines - metabolism; Phosphoric Diester Hydrolases - metabolism; plasma membranes; Rats; Rats, Inbred Strains; sphingomyelin; Sphingomyelin Phosphodiesterase - metabolism; sphingomyelinase; Sphingomyelins - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0531-5565; 1873-6815
• DOI: 10.1016/0531-5565(88)90016-2

The age-induced changes of some phospholipid fractions, membrane fluidity and neutral membrane-bound sphingomyelinase (EC 3.1.4.12) activity in rat liver plasma membranes have been investigated. Alterations in the percentage participation of phosphatidylcholine and sphingomyelin with aging have been established. Regression analysis indicated a positive linear correlation ( r = 0.927) between the membrane-bound neutral sphingomyelinase activity and the phosphatidylcholine percent in the total plasma membrane phospholipids, as well as a negative linear correlation ( r = −0.937) between the enzyme activity and the spingomyelin/phosphatidylcholine ratio.