Quantitation of 5-hydroxymethylfurfural (5-HMF) and related substances in dextrose injections containing drugs and bisulfite

The spectrophotometric test for 5-hydroxymethylfurfural and related substances, which is included in multiple compendial monographs for dextrose-containing injections, was modified to eliminate interference of bisulfite anion. Experimental formulations containing heparin or dopamine hydrochloride we...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1996-02, Vol.14 (4), p.429-434
Main Authors: Hryncewicz, Cheryl L., Koberda, Michael, Konkowski, Mary S.
Format: Article
Language:English
Subjects:
5-Hydroxymethylfuraldehyde
5-Hydroxymethylfurfural
Analysis
Biological and medical sciences
Bisulfite
Dopamine
Dopamine - analysis
Furaldehyde - analogs & derivatives
Furaldehyde - analysis
General pharmacology
Glucose - analysis
Heparin
Medical sciences
Pharmacology. Drug treatments
Spectrophotometry
Spectrophotometry, Ultraviolet
Sulfites - analysis
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Description
Summary:The spectrophotometric test for 5-hydroxymethylfurfural and related substances, which is included in multiple compendial monographs for dextrose-containing injections, was modified to eliminate interference of bisulfite anion. Experimental formulations containing heparin or dopamine hydrochloride were used in this study. The modified assay was shown to be accurate, precise and rugged. With an appropriate standard, the method can be used to measure 5-HMF in solutions with an approximate quantitation limit of 0.06 ppm.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(95)01622-8