Kinetochore function: molecular motors, switches and gates

Kinetochores are essential for accurate chromosome segregation. Recent studies reveal that vertebrate kinetochores are sophisticated propulsion systems composed of not only force generators but also ‘navigation’ and ‘fail-safe’ mechanisms. Advances toward the understanding of the biochemical composi...

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Bibliographic Details
Published in:Current opinion in cell biology 1996-06, Vol.8 (3), p.381-388
Main Authors: Yen, Tim J, Schaar, Bruce T
Format: Article
Language:English
Subjects:
Animals
Kinesin - physiology
Kinetochores - chemistry
Kinetochores - physiology
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Summary:Kinetochores are essential for accurate chromosome segregation. Recent studies reveal that vertebrate kinetochores are sophisticated propulsion systems composed of not only force generators but also ‘navigation’ and ‘fail-safe’ mechanisms. Advances toward the understanding of the biochemical composition and activities of the components of the kinetochore have come from the molecular characterization of key proteins of the kinetochore complex.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(96)80014-7