Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results

Deficits in sensorimotor gating, defined by prepulse inhibition (PPI), have been associated with subcortical dopaminergic overactivity in animal and clinical studies. Utilizing supraorbital nerve electrical stimulation, we produced adequate blink responses and measured decreases in amplitude resulti...

Full description

Saved in:
Bibliographic Details
Published in:Biological psychiatry (1969) 1996, Vol.39 (1), p.33-41
Main Authors: Castellanos, F. Xavier, Fine, Edward J., Kaysen, Debra, Marsh, Wendy L., Rapoport, Judith L., Hallett, Mark
Format: Article
Language:English
Subjects:
Adolescent
Arousal - physiology
Attention - physiology
Attention Deficit Disorder with Hyperactivity - diagnosis
Attention Deficit Disorder with Hyperactivity - physiopathology
Attention Deficit Disorder with Hyperactivity - psychology
Attention deficit disorders. Hyperactivity
attention-deficit/hyperactivity disorder
Biological and medical sciences
blink reflex
Blinking - physiology
Cerebral Cortex - physiopathology
Child
Child clinical studies
Comorbidity
Dopamine - physiology
gating
Globus Pallidus - physiopathology
Humans
Male
Medical sciences
Neural Inhibition - physiology
Neurologic Examination
Prepulse inhibition
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reaction Time - physiology
Reflex, Startle - physiology
Sensory Thresholds - physiology
Tourette Syndrome - diagnosis
Tourette Syndrome - physiopathology
Tourette Syndrome - psychology
Tourette's syndrome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Deficits in sensorimotor gating, defined by prepulse inhibition (PPI), have been associated with subcortical dopaminergic overactivity in animal and clinical studies. Utilizing supraorbital nerve electrical stimulation, we produced adequate blink responses and measured decreases in amplitude resulting from electric prestimuli just above sensory threshold. Seven boys comorbid for attention-deficit hyperactivity disorder (ADHD) and a tic disorder had significantly reduced PPI, compared to 14 screened controls and seven boys with ADHD alone. If independently replicated, these results may reflect greater neurologic immaturity in these comorbid subjects. Alternatively, these findings, together with other converging lines of evidence, suggest that deficient pallidal inhibition may be etiologically related to tic and movement disorders.
ISSN:0006-3223
1873-2402
DOI:10.1016/0006-3223(95)00101-8