Protective effect of UL-409, a herbal formulation against physical and chemical factor induced gastric and duodenal ulcers in experimental animals

UL-409, a herbal formulation, was investigated for its possible ulcero-protective activity in Wistar rats of either sex and male guinea pigs. Oral administration of UL-409 at a dose of 600 mg/kg significantly prevented the occurrence of cold-restraint stress induced ulcerations. It significantly inh...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1996-07, Vol.52 (3), p.165-169
Main Authors: Mitra, S.K., Gopumadhavan, S., Hemavathi, T.S., Muralidhar, T.S., Venkataranganna, M.V.
Format: Article
Language:English
Subjects:
Animals
Anti-Ulcer Agents - therapeutic use
anti-ulcerogenic agents
Antiulcer activity
Ayurvedic medicine
Biological and medical sciences
cytoprotectants
Duodenal Ulcer - etiology
Duodenal Ulcer - prevention & control
duodenal ulcers
Female
Gastric cytoprotection
Gastric Mucosa - drug effects
gastrointestinal agents
General pharmacology
Guinea Pigs
Male
Medical sciences
medicinal plants
Medicine, Ayurvedic
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal
protectants
Rats
Stomach Ulcer - etiology
Stomach Ulcer - prevention & control
stomach ulcers
traditional medicine
UL-409
Wistar rats
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Summary:UL-409, a herbal formulation, was investigated for its possible ulcero-protective activity in Wistar rats of either sex and male guinea pigs. Oral administration of UL-409 at a dose of 600 mg/kg significantly prevented the occurrence of cold-restraint stress induced ulcerations. It significantly inhibited gastric ulceration induced by alcohol and aspirin, as well as cysteamine and histamine induced duodenal ulcers in rats and guinea pigs, respectively. The volume and acidity of gastric juice in pyloric ligated rats was reduced by UL-409. It also significantly, and dose dependently, promoted gastric mucus secretion in normal as well as in stress, drug and alcohol induced ulceration in animals. On the basis of these observations, we conclude that UL-409 possesses antiulcer activity and that the observed activity may be due to the modulation of defensive factors by improvement in gastric cytoprotection.
ISSN:0378-8741
1872-7573
DOI:10.1016/0378-8741(95)01414-4