Hypertonic hemolysis in patients with a mood disorder

• Published in: Biological psychiatry (1969) 1996, Vol.39 (1), p.11-15
• Main Authors: Hoeksema, Ton, Goekoop, Jaap G., Van Kempen, Godfried M.J.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Aged; Biological and medical sciences; Bipolar Disorder - blood; Bipolar Disorder - genetics; Depressive Disorder - blood; Depressive Disorder - genetics; Erythrocytes; Female; hemolysis; Hemolysis - genetics; Hemolysis - physiology; Humans; Male; Mania; Medical sciences; Middle Aged; Mood disorders; Osmotic Fragility - genetics; Osmotic Fragility - physiology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Risk Factors
• ISSN: 0006-3223; 1873-2402
• DOI: 10.1016/0006-3223(95)00106-9

Hypertonic hemolysis was increased in patients with a manic episode ( n = 6, mean NaCl concentration in mol/L at which 50% of the erythrocytes was hemolyzed (H 50) 3.24 ± 0.10), compared to healthy controls ( n = 12, mean H 50 3.43 ± 0.13) ( p ≤ 0.02) and patients with a nonaffective psychotic disorder ( n = 15, mean H 50 3.42 ± 0.18) ( p ≤ 0.02). Compared to these two control groups, hypertonic hemolysis was decreased in patients with a severe depressive episode ( n = 8, mean H 50 3.62 ± 0.19) ( p ≤ 0.05 and p ≤ 0.02, respectively). Within the total depressed patient group, the patients with an increased genetic vulnerability ( n = 8, mean H 50 3.68 ± 0.16) showed a decreased hypertonic hemolysis compared to the other depressed patients ( n = 14, mean H 50 3.40 ± 0.16) ( p ≤ 0.002).