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Amphetamine and negative symptoms of schizophrenia

The purpose of this study was to assess further the effect of amphetamine on negative symptoms of schizophrenia. Thirty-seven schizophrenic males meeting DSM-III criteria were rated with the Brief Psychiatric Rating Scale, the Abrams and Taylor Scale, and the Abnormal Involuntary Movements Scale bef...

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Bibliographic Details
Published in:Psychopharmacologia 1996, Vol.123 (2), p.211-214
Main Authors: SANFILIPO, M, WOLKIN, A, ANGRIST, B, VAN KAMMEN, D. P, DUNCAN, E, WIELAND, S, COOPER, T. B, PESELOW, E. D, ROTROSEN, J
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Language:English
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Summary:The purpose of this study was to assess further the effect of amphetamine on negative symptoms of schizophrenia. Thirty-seven schizophrenic males meeting DSM-III criteria were rated with the Brief Psychiatric Rating Scale, the Abrams and Taylor Scale, and the Abnormal Involuntary Movements Scale before and after double-blind administration of either amphetamine (n = 26) or placebo (n = 11). Our results indicated that amphetamine administration generally did not improve negative symptoms, even when accounting for changes in positive symptoms. However, greater baseline negative symptoms were associated with a modest diminution after amphetamine treatment. Therefore, amphetamine may modestly improve negative symptoms in those schizophrenics in whom this symptomatology is more severe.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02246180