I/D polymorphism at the locus for ACE and apo A-I gene promoter polymorphism as risk factors for coronary artery disease in patients with familial hypercholesterolemia

In our study we searched for an association between the insertion/deletion (I/D) polymorphism at the ACE locus as well as apo A-I promoter polymorphism and coronary artery disease (CAD) in patients with familial hypercholesterolemia (FH). 34 FH patients over 40 years were ascertained; 16 patients wi...

Full description

Saved in:
Bibliographic Details
Published in:Pflügers Archiv 1996, Vol.431 (6 Suppl 2), p.R197-R198
Main Authors: Petrovic, D, Kleber, I, Zorc, M, Peterlin, B
Format: Article
Language:English
Subjects:
Adult
Apolipoprotein A-I - genetics
Base Sequence
Coronary Disease - genetics
Genotype
Humans
Hyperlipoproteinemia Type II - genetics
Molecular Sequence Data
Mutation
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic - genetics
Promoter Regions, Genetic
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In our study we searched for an association between the insertion/deletion (I/D) polymorphism at the ACE locus as well as apo A-I promoter polymorphism and coronary artery disease (CAD) in patients with familial hypercholesterolemia (FH). 34 FH patients over 40 years were ascertained; 16 patients with CAD were compared with 18 patients without CAD. There was an excess of DD or ID genotype in FH patients with CAD (OR = 4.9, CI = 1.17-22.17; Fisher exact p = 0.012), however, no association between G to A substitution in the promoter region of the apo A-I gene and CAD was found. Our results suggest that the DD/ID genotype at the ACE gene locus might be an important genetic risk factor for CAD in FH patients.
ISSN:0031-6768
1432-2013
DOI:10.1007/bf02346336