Activation of the lamin A gene during rat liver development

We have studied the regulation of expression of the A-type lamins, which are constituents of the nuclear lamina. During rat liver development, high levels of lamin A and C mRNAs were observed in 15-day fetal liver but were barely detectable in the adult. The chromatin conformation of the lamin A gen...

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Bibliographic Details
Published in:FEBS letters 1996-08, Vol.392 (2), p.137-142
Main Authors: Hamid, Q.Anwar, Fatima, Soghra, Thanumalayan, Subramonian, Parnaik, Veena K.
Format: Article
Language:English
Subjects:
Animals
Blotting, Northern
Cell Line
Chromatin - metabolism
Deoxyribonuclease I - metabolism
Gene Expression Regulation, Developmental
Lamin A gene
Lamin Type A
Lamins
Liver - enzymology
Liver - metabolism
Liver development
Nuclear lamina
Nuclear Proteins - genetics
Rats
Rats, Wistar
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcription, Genetic
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Summary:We have studied the regulation of expression of the A-type lamins, which are constituents of the nuclear lamina. During rat liver development, high levels of lamin A and C mRNAs were observed in 15-day fetal liver but were barely detectable in the adult. The chromatin conformation of the lamin A gene was sensitive to DNase I in 15-day fetal liver but became mostly insensitive in the adult. Lamin A and C proteins could be detected in fetal liver and persisted in the adult. Our evidence suggests that the lamin A gene is actively transcribed early in liver differentiation and its activity declines considerably in adult liver.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(96)00802-2