Mutation of low affinity nerve growth factor receptor gene is associated with the hypertensive phenotype in spontaneously hypertensive inbred rat strains

We previously reported a missense mutation in the low affinity nerve growth factor receptor (LNGFR) gene of spontaneously hypertensive rats (SHR), proposing this gene as a promising candidate in genetic hypertension. In this study we provide further support for implicating this gene in genetic hyper...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 1996-05, Vol.210 (1), p.69-72
Main Authors: Nemoto, Kiyomitsu, Kageyama, Haruaki, Ueyama, Takashi, Fukamachi, Katsumi, Sekimoto, Masashi, Tomita, Isao, Senba, Emiko, Forehand, Cynthia J., Hendley, Edith D.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Arterial hypertension. Arterial hypotension
Base Sequence
Behavior, Animal - physiology
Behavioral hyperactivity
Biological and medical sciences
Blood and lymphatic vessels
Blood Vessels - chemistry
Cardiology. Vascular system
Experimental diseases
Hypertension
Hypertension - genetics
Low affinity nerve growth factor receptor
Medical sciences
Molecular Sequence Data
Nerve growth factor
Nerve Growth Factors - analysis
Nucleotide sequence
Phenotype
Point mutation
Point Mutation - physiology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Nerve Growth Factor - genetics
RNA, Messenger - analysis
Spontaneously hypertensive rat
Transcription, Genetic - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We previously reported a missense mutation in the low affinity nerve growth factor receptor (LNGFR) gene of spontaneously hypertensive rats (SHR), proposing this gene as a promising candidate in genetic hypertension. In this study we provide further support for implicating this gene in genetic hypertension using two new inbred strains, WKHT and WKHA rats. These strains originated from crossbreeding SHR rats with normotensive Wistar-Kyoto rats (WKY): WKHT rats are hypertensive but not hyperactive, and WKHA rats are hyperactive but not hypertensive. Nucleotide sequence analysis of the LNGFR gene revealed that WKHT has the same mutation as SHR, whereas WKHA has the normal sequence, as seen in WKY. These results support our original hypothesis that the mutated LNGFR gene is linked to hypertension, since the mutation had co-segregated with the hypertensive trait, and not hyperactivity trait of SHR.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(96)12664-1