Adolescent growth and maturation in zinc-deprived rhesus monkeys [see comment]

Growth retardation has been associated with zinc deficiency in adolescent human populations, but animal models were not available previously to explore this syndrome. Moderate dietary zinc deprivation (2 micrograms Zn/g diet) was introduced in female rhesus monkeys (Macaca mulatta; n = 10) from the...

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Bibliographic Details
Published in:The American journal of clinical nutrition 1996-09, Vol.64 (3), p.274-282
Main Authors: Golub, MS, Keen, CL, Gershwin, ME, Styne, DM, Takeuchi, PT, Ontell, F, Walter, RM, Hendrickx, AG
Format: Article
Language:English
Subjects:
Aging - metabolism
Animals
Biological and medical sciences
Body Composition
Body Height
Body Weight
Bone Density
Bone Development
Bones
Diet
Eating
Female
Females
Macaca mulatta - growth & development
Macaca mulatta - metabolism
Medical sciences
Menstruation
Metabolic diseases
Monkeys & apes
Nutrition
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Physical growth
Sexual Maturation
Zinc
Zinc - deficiency
Zinc - metabolism
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Summary:Growth retardation has been associated with zinc deficiency in adolescent human populations, but animal models were not available previously to explore this syndrome. Moderate dietary zinc deprivation (2 micrograms Zn/g diet) was introduced in female rhesus monkeys (Macaca mulatta; n = 10) from the beginning of puberty through menarche. Subgroups of animals (n = 4) continued to be fed the zinc-deficient diet through 45 mo of age (sexual maturity). Reduced weight gain and linear growth and lower plasma zinc concentrations (11.8 +/- 0.6 and 9.2 +/- 0.8 mumol/L in control and zinc-deficient monkeys, respectively) were evident during the premenarcheal growth spurt. Slower skeletal growth, maturation, and mineralization were recorded in the postmenarcheal period and some indicators of sexual maturation were delayed. Food intake was slightly higher in the zinc-deficient group than in controls. These data confirm that adolescent growth and maturation are vulnerable to disruption by moderate dietary zinc deprivation in nonhuman primates.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/64.3.274