Ultrastructure of Human Immunodeficiency Virus Type 2

Division of Viral Diseases and 1 AIDS Program, Center for Infectious Diseases, Centers for Disease Control, 1600 Clifton Road, Atlanta, Georgia 30333, U.S.A. The ultrastructure of human immunodeficiency virus type 2 (HIV-2) was determined by negative stain and thin section electron microscopy (EM)....

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Bibliographic Details
Published in:Journal of general virology 1988-06, Vol.69 (6), p.1425-1429
Main Authors: Palmer, Erskine, Martin, Mary Lane, Goldsmith, Cynthia, Switzer, William
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - microbiology
Africa, Western
AIDS/HIV
Cell Line
HIV - ultrastructure
human immunodeficiency virus 2
Humans
Macrophages - microbiology
Microscopy, Electron
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Summary:Division of Viral Diseases and 1 AIDS Program, Center for Infectious Diseases, Centers for Disease Control, 1600 Clifton Road, Atlanta, Georgia 30333, U.S.A. The ultrastructure of human immunodeficiency virus type 2 (HIV-2) was determined by negative stain and thin section electron microscopy (EM). Some virus particles had surface projections about 10 nm in length which were evenly spaced. Nonidet P40-treated particles which were penetrated by stain revealed a distinctive off-centre cone-shaped core and, in addition, free-lying cores were also seen in detergent-treated preparations. The surface of the cores was composed of a layer of small subunits. The structure of HIV-2 determined by thin section EM was the same as that deduced by negative stain EM. Keywords: AIDS, HIV-2, electron microscopy Received 3 November 1987; accepted 29 February 1988.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-69-6-1425