Farnesol and Geranylgeraniol Induce Actin Cytoskeleton Disorganization and Apoptosis in A549 Lung Adenocarcinoma Cells

The effects of exogenous isoprenoids were investigated on A549 human lung adenocarcinoma cells. Among the tested isoprenoids, only farnesol and geranylgeraniol induce actin cytoskeleton disorganization, growth inhibition, and apoptosis. In contrast, desmosterol leads only to growth inhibition. We sh...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 1996-08, Vol.225 (3), p.869-876
Main Authors: Miquel, Karine, Pradines, Anne, Favre, Gilles
Format: Article
Language:English
Subjects:
Actins - metabolism
Apoptosis - drug effects
Cholesterol - pharmacology
Cytoskeleton - drug effects
Cytoskeleton - metabolism
Desmosterol - pharmacology
Diterpenes - pharmacology
Enzyme Inhibitors - pharmacology
Farnesol - pharmacology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Mevalonic Acid - pharmacology
Squalene - pharmacology
Terpenes - pharmacology
Tumor Cells, Cultured
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of exogenous isoprenoids were investigated on A549 human lung adenocarcinoma cells. Among the tested isoprenoids, only farnesol and geranylgeraniol induce actin cytoskeleton disorganization, growth inhibition, and apoptosis. In contrast, desmosterol leads only to growth inhibition. We show that all tested isoprenoids are potent inhibitors of HMG CoA reductase activity, the sterols being the most powerful while they induce neither F-actin disorganization nor apoptosis. Thus the molecular mechanisms induced by farnesol and geranylgeraniol appear independent of reductase regulation. Our results point out the specific role of farnesol and geranylgeraniol on actin cytoskeleton organization and apoptosis in adenocarcinoma cells.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1996.1265