Immunoregulatory properties of growth hormone and prolactin

Reciprocal communication between the neuroendocrine and immune systems is critical to the establishment of host homeostatic and defence mechanisms. The production and utilisation of common ligands and their receptors by cells of the immune and neuroendocrine systems constitutes a biochemical informa...

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Bibliographic Details
Published in:Pharmacology & therapeutics (Oxford) 1996, Vol.69 (3), p.237-257
Main Author: Weigent, Douglas A.
Format: Article
Language:English
Subjects:
biosynthesis
Growth hormone
Growth Hormone - biosynthesis
Growth Hormone - immunology
Growth Hormone - pharmacology
Growth Hormone - physiology
Humans
immunoregulation
lymphocytes
prolactin
Prolactin - biosynthesis
Prolactin - immunology
Prolactin - pharmacology
Prolactin - physiology
receptors
Receptors, Prolactin - genetics
Receptors, Prolactin - immunology
Receptors, Prolactin - metabolism
Receptors, Somatotropin - genetics
Receptors, Somatotropin - immunology
Receptors, Somatotropin - metabolism
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Summary:Reciprocal communication between the neuroendocrine and immune systems is critical to the establishment of host homeostatic and defence mechanisms. The production and utilisation of common ligands and their receptors by cells of the immune and neuroendocrine systems constitutes a biochemical information circuit between and within the immune and neuroendocrine systems. Although the structures of the various signalling components appear to be similar in both systems, the regulation of their synthesis may be different. Growth hormone and prolactin have similar and marked influences on the function/activity of each of the major immune cell types, both in vitro and in vivo. The underlying molecular mechanisms are just beginning to be unravelled, and it is anticipated that further work in this rapidly developing field will establish abnormal pituitary and/or lymphocyte growth hormone and prolactin synthesis and function as a contributory factor to a number of pathologic situations, including leukaemia and autoimmunity.
ISSN:0163-7258
1879-016X
DOI:10.1016/0163-7258(96)00001-0