An immunohistochemical analysis of anti-amylase antibody reactivity in acinic cell adenocarcinoma

In many salivary acinic cell adenocarcinomas, well-differentiated serous acinar-type cells may be few and inconspicuous. In these cases it may be difficult to distinguish acinic cell adenocarcinoma from other types of salivary gland neoplasms such as cystadenocarcinoma. The usefulness of antisalivar...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 1996-06, Vol.81 (6), p.691-694
Main Authors: Childers, Esther L.B., Ellis, Gary L., Auclair, Paul L.
Format: Article
Language:English
Subjects:
Amylases - metabolism
Antibodies, Monoclonal
Biological and medical sciences
Carcinoma, Acinar Cell - diagnosis
Carcinoma, Acinar Cell - enzymology
Dentistry
Humans
Immunoenzyme Techniques
Medical sciences
Otorhinolaryngology. Stomatology
Parotid Neoplasms - diagnosis
Parotid Neoplasms - enzymology
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:In many salivary acinic cell adenocarcinomas, well-differentiated serous acinar-type cells may be few and inconspicuous. In these cases it may be difficult to distinguish acinic cell adenocarcinoma from other types of salivary gland neoplasms such as cystadenocarcinoma. The usefulness of antisalivary amylase antibody immunohistochemical staining as a diagnostic aid was assessed on paraffin-embedded tissue sections from 27 typical acinic cell adenocarcinomas. Only 4 of 27 tumors showed reactivity in tumor cells. We conclude that anti-amylase antibody is of limited value in the recognition of acinic cell adenocarcinoma when light morphologic features are insufficient for diagnosis.
ISSN:1079-2104
1528-395X
DOI:10.1016/S1079-2104(96)80075-8