Thrombus precursor protein (TpP): marker of thrombosis early in the pathogenesis of myocardial infarction

We have developed an enzyme-linked immunosorbent immunoassay for quantifying the immediate precursor proteins to intravascular thrombi. This thrombus precursor protein (TpP) assay identifies active thrombosis in several clinical conditions, including early myocardial infarction (MI). In a study of p...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 1996-09, Vol.42 (9), p.1537-1541
Main Authors: Carville, DG, Dimitrijevic, N, Walsh, M, Digirolamo, T, Brill, EM, Drew, N, Gargan, PE
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers
Cardiology. Vascular system
Chest Pain
Coronary heart disease
Creatine Kinase - blood
Emergency Service, Hospital
Enzyme-Linked Immunosorbent Assay - methods
Female
Heart
Humans
Isoenzymes
Male
Medical sciences
Middle Aged
Myocardial Infarction - diagnosis
Prothrombin - analysis
Reference Values
Thrombosis - diagnosis
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Summary:We have developed an enzyme-linked immunosorbent immunoassay for quantifying the immediate precursor proteins to intravascular thrombi. This thrombus precursor protein (TpP) assay identifies active thrombosis in several clinical conditions, including early myocardial infarction (MI). In a study of patients recruited for the GUSTO intervention study, MI patients had concentrations of TpP 4-20-fold that of controls; patients diagnosed without MI had concentrations similar to the control subjects. In a separate study of subjects presenting at the emergency room with chest pain, MI patients who presented early after the onset of chest pain had TpP concentrations significantly (P
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/42.9.1537