Deoxyribonucleic acid profiling by restriction fragment length polymorphism analysis – a compilation of validation studies

In preparation for the application of restriction fragment length polymorphism (RFLP) analysis methods to casework, validation studies were performed at the Indianapolis-Marion County Forensic Services Agency (IMCFSA). They encompassed the following areas: standard specimens, sample consistency, rep...

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Bibliographic Details
Published in:Science & justice 1996-07, Vol.36 (3), p.173-182
Main Authors: Tahir, M.A., Caruso, J.F., Hamby, P.P., Sovinski, S.M.
Format: Article
Language:English
Subjects:
Blood
Blood Stains
Body fluids
Deoxyribonucleic Acid (DNA)
DNA - analysis
DNA Fingerprinting
Female
Forensic Science
Humans
Male
Polymorphism, Restriction Fragment Length
Reproducibility of Results
Restriction Fragment Length Polymorphism (RFLP)
Semen
Vaginal Smears
Validation
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Summary:In preparation for the application of restriction fragment length polymorphism (RFLP) analysis methods to casework, validation studies were performed at the Indianapolis-Marion County Forensic Services Agency (IMCFSA). They encompassed the following areas: standard specimens, sample consistency, reproducibility, mixed specimens, environmental insults, minimum sample requirements, non-probative casework, repetitive sizing accuracy, precision and match criteria analysis, and population studies including K562 data analysis. All studies yielded results as expected, were consistent with those previously reported by other laboratories, and formed a strong foundation on which to base future casework analysis.
ISSN:1355-0306
1876-4452
DOI:10.1016/S1355-0306(96)72592-3