Magnetic Resonance Brain Images in Schizophrenic and Normal Subjects: Influence of Diagnosis and Education

Evidence from computerized tomography (CT) suggests that schizophrenic patients may have smaller brains than normal subjects. Magnetic resonance imaging (MRI), which produces more clearly defined images than CT, was used to measure T1 and brain size of 24 schizophrenic and 24 normal subjects matched...

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Bibliographic Details
Published in:Schizophrenia bulletin 1988, Vol.14 (1), p.21-37
Main Authors: DeMyer, Marian K., Gilmor, Richard L., Hendrie, Hugh C., DeMyer, William E., Augustyn, Gary T., Jackson, Roger K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Brain - pathology
Brain Weight
Cerebral Ventricles
Cerebral Ventricles - pathology
Dominance, Cerebral - physiology
Educational Status
Female
Frontal Lobe
Frontal Lobe - pathology
Human
Humans
Inpatient
Magnetic Resonance Imaging
Male
Medical sciences
Miscellaneous
Neurocognitive Disorders - pathology
Neuroimaging
Neuropsychological Tests
Outpatient
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Schizophrenia
Schizophrenia - pathology
Schizophrenic Psychology
Techniques and methods
Tomography
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Summary:Evidence from computerized tomography (CT) suggests that schizophrenic patients may have smaller brains than normal subjects. Magnetic resonance imaging (MRI), which produces more clearly defined images than CT, was used to measure T1 and brain size of 24 schizophrenic and 24 normal subjects matched for age and sex but not for education. Two transverse images were obtained: slice 1 at the foramina of Monro and slice 2 at the widest part of the lateral ventricles. Adequate T1 instrumental reliability could not be demonstrated. Schizophrenic subjects had smaller right hemispheres (slice 1) and smaller frontal areas (slice 2) than normal subjects. However, when education was taken into account, only the left frontal area (slice 2) was smaller in schizophrenic than in normal subjects. Larger brain areas were associated with better cognitive test scores and fewer neurological signs. Cranial and body size were similar in both diagnostic groups.
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/14.1.21