Negative symptoms and EEG alpha in schizophrenia: a replication

The authors previously reported that negative symptoms were associated with reduced EEG alpha power and coherence in medication-free schizophrenic inpatients. These post-hoc findings were based on resting EEG data in an eyes open condition. This report describes the replication of these results in a...

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Bibliographic Details
Published in:Schizophrenia research 1996-05, Vol.19 (2), p.151-161
Main Authors: Merrin, Edward L., Floyd, Thomas C.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Alpha
Alpha Rhythm
Arousal - physiology
Attention - physiology
Biological and medical sciences
Depression - diagnosis
Depression - physiopathology
Depression - psychology
Dominance, Cerebral - physiology
EEG
Electroencephalography
Frontal Lobe - physiopathology
Humans
Male
Medical sciences
Middle Aged
Negative symptoms
Parietal Lobe - physiopathology
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reproducibility of Results
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Schizophrenic Psychology
Signal Processing, Computer-Assisted
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Summary:The authors previously reported that negative symptoms were associated with reduced EEG alpha power and coherence in medication-free schizophrenic inpatients. These post-hoc findings were based on resting EEG data in an eyes open condition. This report describes the replication of these results in a new sample of 17 male veterans (age 38±8) recently hospitalized with DSM-III-R schizophrenia. All patients had been free of neuroleptic medication at least 12–14 days. The relationships between resting alpha (7.5–12.5 Hz) power and coherence and symptom ratings (as measured by subscales derived from the Brief Psychiatric Rating Scale) were examined with multivariate repeated measure analyses of covariance. Results were similar to those obtained earlier, with a main effect of negative symptoms ( p = 0.05) on log alpha power, a localized effect on right frontal-parietal alpha coherence ( p < 0.02), and a main effect ( p
ISSN:0920-9964
1573-2509
DOI:10.1016/0920-9964(96)88522-7