Panencephalitic Creutzfeldt-Jakob disease Unusual presentation of magnetic resonance imaging and proton magnetic resonance spectroscopy

We present serial magnetic resonance imaging (MRI) scans on a biopsy-verified case of Creutzfeldt-Jakob disease (CJD). The initial MRI scan demonstrated increased T2 signal-intensity within the basal ganglia and thalami. Subsequent MRI scans demonstrated a thin cortex, increased T2 signals diffusely...

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Bibliographic Details
Published in:Journal of the neurological sciences 1996-06, Vol.138 (1), p.157-160
Main Authors: Shyu, Woei-Cherng, Lee, Chau-Chin, Hsu, Yaw-Don, Lin, Jiann-Chyun, Lee, Jiunn-Tay, Lee, Wei-Hwa, Tsao, Wen-Long
Format: Article
Language:English
Subjects:
Basal ganglion
Biological and medical sciences
Biopsy
Brain - pathology
Cerebral Cortex - pathology
Creutzfeldt-Jakob disease
Creutzfeldt-Jakob Syndrome - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Female
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy - methods
Medical sciences
Middle Aged
MRI
MRS
Neurology
Protons
Spongiform encephalopathy
Tropical medicine
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Summary:We present serial magnetic resonance imaging (MRI) scans on a biopsy-verified case of Creutzfeldt-Jakob disease (CJD). The initial MRI scan demonstrated increased T2 signal-intensity within the basal ganglia and thalami. Subsequent MRI scans demonstrated a thin cortex, increased T2 signals diffusely within the white matter including U-fibers, and hypointense T2 signals within the basal ganglia, and thalami. Proton magnetic resonance spectroscopy ( 1H-MRS) study showed an absence of creatine, choline and N-acetylaspartate signals. By these characteristic findings, serial MRI and MRS studies may be helpful in differentiating CJD from other dementing illnesses.
ISSN:0022-510X
1878-5883
DOI:10.1016/0022-510X(96)00010-X