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Type-Restricted Neutralization of Molecular Clones of Human Immunodeficiency Virus
In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-III$_{\text{B}}$ by an extensive panel of sera was compared. Sera fr...
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Published in: | Science (American Association for the Advancement of Science) 1988-07, Vol.241 (4863), p.357-359 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-III$_{\text{B}}$ by an extensive panel of sera was compared. Sera from HIV-1--infected patients and from goats immunized with polyacrylamide gel--purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such ``clonal restriction'' of neutralizing activity. |
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ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.3388046 |