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Type-Restricted Neutralization of Molecular Clones of Human Immunodeficiency Virus

In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-III$_{\text{B}}$ by an extensive panel of sera was compared. Sera fr...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1988-07, Vol.241 (4863), p.357-359
Main Authors: Looney, David J., Fisher, Amanda G., Putney, Scott D., Rusche, James R., Redfield, Robert R., Burke, Donald S., Gallo, Robert C., Wong-Staal, F.
Format: Article
Language:English
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Summary:In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-III$_{\text{B}}$ by an extensive panel of sera was compared. Sera from HIV-1--infected patients and from goats immunized with polyacrylamide gel--purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such ``clonal restriction'' of neutralizing activity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3388046