Discrimination of the determinant specificity of two competitive Semliki Forest virus neutralizing monoclonal antibodies by anti-idiotypic antibodies

The two highly competitive, monoclonal antibodies (MAs), UM 5.1 and UM 8.1, recognize on the E2 glycoprotein of Semliki Forest virus different determinants as indicated by the absence of cross-reactive anti-idiotypic antibodies in rabbit immune sera induced against these highly neutralizing MAs.

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Bibliographic Details
Published in:Archives of virology 1988, Vol.100 (1-2), p.115-120
Main Authors: OOSTERLAKEN, T. A. M, KRAAIJEVELD, C. A, SNIJDERS, A, HARMSEN, M, BENAISSA-TROUW, B. J, SNIPPE, H
Format: Article
Language:English
Subjects:
Animals
Antibodies, Anti-Idiotypic
Antibodies, Monoclonal
Antibody Specificity
Binding, Competitive
Biological and medical sciences
Epitopes - analysis
Fundamental and applied biological sciences. Psychology
Immunoglobulin Idiotypes - immunology
L Cells (Cell Line)
Mice
Microbiology
Neutralization Tests
Semliki Forest virus
Semliki forest virus - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Viral Proteins - immunology
Virology
Virus Cultivation
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Description
Summary:The two highly competitive, monoclonal antibodies (MAs), UM 5.1 and UM 8.1, recognize on the E2 glycoprotein of Semliki Forest virus different determinants as indicated by the absence of cross-reactive anti-idiotypic antibodies in rabbit immune sera induced against these highly neutralizing MAs.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01310913