A Synthesis of the Amaryllidaceae Alkaloid Pratosine

A synthesis of pratosine by thermolysis of the Michael adduct obtained from 5-hydroxy-8,9-dimethoxy-6(5H)-phenanthridone and methyl propiolate is described.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1996-08, Vol.59 (8), p.744-747
Main Authors: Pereira, M. Manuela A, Prabhakar, Sundaresan, Lobo, Ana M
Format: Article
Language:English
Subjects:
ALCALOIDE
ALCALOIDES
ALKALOIDS
Alkaloids - chemical synthesis
Alkaloids - chemistry
BIOCHEMICAL PATHWAYS
CHEMICAL COMPOSITION
CHEMICAL REACTIONS
Chemistry
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CRINUM
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Hydrogen-Ion Concentration
Hydrolysis
Lactams - chemistry
Magnetic Resonance Spectroscopy
Molecular Weight
Organic chemistry
PHARMACEUTICAL PRODUCTS
Plant Extracts - chemistry
PRECURSORS
Preparations and properties
REACCIONES QUIMICAS
REACTION CHIMIQUE
VIA BIOQUIMICA DEL METABOLISMO
VOIE BIOCHIMIQUE DU METABOLISME
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Description
Summary:A synthesis of pratosine by thermolysis of the Michael adduct obtained from 5-hydroxy-8,9-dimethoxy-6(5H)-phenanthridone and methyl propiolate is described.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9601869