Organization of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences

We present a detailed picture of the disposition of the histone genes in the chicken genome and an almost complete set of the core histone protein sequences. Thirty-nine histone genes, six H1, nine H2A, eight H2B, eight H3 and eight H4, were located within a histone gene cluster of 110 kb, which was...

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Bibliographic Details
Published in:DNA research 1996, Vol.3 (2), p.95-99
Main Authors: Takami, Y, Higashio, M, Fukuoka, T, Takechi, S, Nakayama, T
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Chickens - genetics
Chromosome Mapping
Cloning, Molecular
Histones - chemistry
Histones - genetics
Multigene Family
Open Reading Frames
Restriction Mapping
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
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Summary:We present a detailed picture of the disposition of the histone genes in the chicken genome and an almost complete set of the core histone protein sequences. Thirty-nine histone genes, six H1, nine H2A, eight H2B, eight H3 and eight H4, were located within a histone gene cluster of 110 kb, which was covered by five cosmid clones and two lambda clones. Results of our sequence analyses, together with those reported previously, generated a set of the core histone amino acid sequences as follows: three H2A variants, four H2B variants, two H3 variants and an H4 protein.
ISSN:1340-2838
DOI:10.1093/dnares/3.2.95