Concentrations of Serum Markers of Type I Collagen Synthesis and Degradation and Serum Osteocalcin in Maternal and Umbilical Circulation

Measurement was made of the serum carboxyl-terminal propeptide of type I procollagen (PICP), carboxyl terminal cross-linked telopeptide of type I collagen (ICTP) and osteocalcin in 17 full-term mother-infant pairs and 17 age-matched nonpregnant women. Serum PICP and ICTP of term women at the time of...

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Published in:ENDOCRINE JOURNAL 1996, Vol.43(2), pp.191-195
Main Authors: YASUMIZU, TAKEHIKO, KATO, JUNZO
Format: Article
Language:English
Subjects:
Biomarkers - blood
Bone and Bones - metabolism
Collagen - biosynthesis
Collagen - blood
Collagen - metabolism
Collagen Type I
Female
Fetal Blood - chemistry
Humans
Infant, Newborn
Maternal and fetal circulation
Osteocalcin
Osteocalcin - blood
Peptide Fragments - blood
Peptides - blood
Pregnancy
Procollagen - blood
Reference Values
Serum marker
Type I collagen
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KATO, JUNZO
description Measurement was made of the serum carboxyl-terminal propeptide of type I procollagen (PICP), carboxyl terminal cross-linked telopeptide of type I collagen (ICTP) and osteocalcin in 17 full-term mother-infant pairs and 17 age-matched nonpregnant women. Serum PICP and ICTP of term women at the time of delivery were significantly higher (P
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Serum PICP and ICTP of term women at the time of delivery were significantly higher (P&lt;0.025, P&lt;0.01, respectively) and serum osteocalcin was significantly lower (P&lt;0.001) than in nonpregnant women. The ratio of PICP to ICTP was essentially the same for term and nonpregnant women. Serum PICP, ICTP, and osteocalcin were virtually the same in the umbilical arteries and vein. PICP, ICTP and osteocalcin were much higher in fetal than maternal circulation (P&lt;0.001). The fetal levels of these proteins were not correlated with maternal levels, nor with birth weight. Thus, during pregnancy, either osteoclastic or osteoblastic activity would appear to increase slightly, but the balance between bone formation and resorption is maintained. During fetal life, bone turnover may be greatly accelerated and bone metabolism may occur independently of maternal bone metabolism.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.43.191</identifier><identifier>PMID: 8793335</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Biomarkers - blood ; Bone and Bones - metabolism ; Collagen - biosynthesis ; Collagen - blood ; Collagen - metabolism ; Collagen Type I ; Female ; Fetal Blood - chemistry ; Humans ; Infant, Newborn ; Maternal and fetal circulation ; Osteocalcin ; Osteocalcin - blood ; Peptide Fragments - blood ; Peptides - blood ; Pregnancy ; Procollagen - blood ; Reference Values ; Serum marker ; Type I collagen</subject><ispartof>Endocrine Journal, 1996, Vol.43(2), pp.191-195</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-330e61446afc0f6969a17501003c6b21b5aa6bbfd8e767a463ae6d96656b85eb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8793335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YASUMIZU, TAKEHIKO</creatorcontrib><creatorcontrib>KATO, JUNZO</creatorcontrib><creatorcontrib>Department of Obstetrics and Gynecology</creatorcontrib><creatorcontrib>Yamanashi Medical University</creatorcontrib><title>Concentrations of Serum Markers of Type I Collagen Synthesis and Degradation and Serum Osteocalcin in Maternal and Umbilical Circulation</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description>Measurement was made of the serum carboxyl-terminal propeptide of type I procollagen (PICP), carboxyl terminal cross-linked telopeptide of type I collagen (ICTP) and osteocalcin in 17 full-term mother-infant pairs and 17 age-matched nonpregnant women. Serum PICP and ICTP of term women at the time of delivery were significantly higher (P&lt;0.025, P&lt;0.01, respectively) and serum osteocalcin was significantly lower (P&lt;0.001) than in nonpregnant women. The ratio of PICP to ICTP was essentially the same for term and nonpregnant women. Serum PICP, ICTP, and osteocalcin were virtually the same in the umbilical arteries and vein. PICP, ICTP and osteocalcin were much higher in fetal than maternal circulation (P&lt;0.001). The fetal levels of these proteins were not correlated with maternal levels, nor with birth weight. Thus, during pregnancy, either osteoclastic or osteoblastic activity would appear to increase slightly, but the balance between bone formation and resorption is maintained. During fetal life, bone turnover may be greatly accelerated and bone metabolism may occur independently of maternal bone metabolism.</description><subject>Biomarkers - blood</subject><subject>Bone and Bones - metabolism</subject><subject>Collagen - biosynthesis</subject><subject>Collagen - blood</subject><subject>Collagen - metabolism</subject><subject>Collagen Type I</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal and fetal circulation</subject><subject>Osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>Peptide Fragments - blood</subject><subject>Peptides - blood</subject><subject>Pregnancy</subject><subject>Procollagen - blood</subject><subject>Reference Values</subject><subject>Serum marker</subject><subject>Type I collagen</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v1DAQtRCoLIUrN6ScuGWx44_YR7SUUqlVD23PluNMWi-JvbWTw_4DfjZOsi1HJH-_N88z8xD6TPCWcFx_A98GG_dbRrdEkTdoQyiTJeMMv0UbrIgspeLqPfqQ0h5jSjmjZ-hM1orm8wb92QVvwY_RjC74VISuuIM4DcWNib8hLg_3xwMUV8Uu9L15BF_cHf34BMmlwvi2-AGP0bRL-HJfw2_TCMGa3jpf5HFjRoje9AvjYWhc7zJY7Fy0U7_EfkTvOtMn-HTaz9HDz4v73a_y-vbyavf9urRC8rGkFIMgjAnTWdwJJZQhNcckl2ZFU5GGGyOapmsl1KI2TFADolVCcNFIDg09R19X3UMMzxOkUQ8uWcileQhT0rWkpJJE_ZdIuJqJOBO3K9HGkFKETh-iG0w8aoL17JE-eaQZ1dmjHPDlpDw1A7Sv9JMpGb9c8QzObQq-dx70PkxzC5O2z2JRzGJKaIwZxZXOLchTkXnhBAsuK_JPaZ_GbN3rTyaOzvbwkljWoXNy1brMKi8M-2RiptG_SCG_nA</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>YASUMIZU, TAKEHIKO</creator><creator>KATO, JUNZO</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Concentrations of Serum Markers of Type I Collagen Synthesis and Degradation and Serum Osteocalcin in Maternal and Umbilical Circulation</title><author>YASUMIZU, TAKEHIKO ; KATO, JUNZO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-330e61446afc0f6969a17501003c6b21b5aa6bbfd8e767a463ae6d96656b85eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biomarkers - blood</topic><topic>Bone and Bones - metabolism</topic><topic>Collagen - biosynthesis</topic><topic>Collagen - blood</topic><topic>Collagen - metabolism</topic><topic>Collagen Type I</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal and fetal circulation</topic><topic>Osteocalcin</topic><topic>Osteocalcin - blood</topic><topic>Peptide Fragments - blood</topic><topic>Peptides - blood</topic><topic>Pregnancy</topic><topic>Procollagen - blood</topic><topic>Reference Values</topic><topic>Serum marker</topic><topic>Type I collagen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YASUMIZU, TAKEHIKO</creatorcontrib><creatorcontrib>KATO, JUNZO</creatorcontrib><creatorcontrib>Department of Obstetrics and Gynecology</creatorcontrib><creatorcontrib>Yamanashi Medical University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YASUMIZU, TAKEHIKO</au><au>KATO, JUNZO</au><aucorp>Department of Obstetrics and Gynecology</aucorp><aucorp>Yamanashi Medical University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concentrations of Serum Markers of Type I Collagen Synthesis and Degradation and Serum Osteocalcin in Maternal and Umbilical Circulation</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>1996</date><risdate>1996</risdate><volume>43</volume><issue>2</issue><spage>191</spage><epage>195</epage><pages>191-195</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>Measurement was made of the serum carboxyl-terminal propeptide of type I procollagen (PICP), carboxyl terminal cross-linked telopeptide of type I collagen (ICTP) and osteocalcin in 17 full-term mother-infant pairs and 17 age-matched nonpregnant women. Serum PICP and ICTP of term women at the time of delivery were significantly higher (P&lt;0.025, P&lt;0.01, respectively) and serum osteocalcin was significantly lower (P&lt;0.001) than in nonpregnant women. The ratio of PICP to ICTP was essentially the same for term and nonpregnant women. Serum PICP, ICTP, and osteocalcin were virtually the same in the umbilical arteries and vein. PICP, ICTP and osteocalcin were much higher in fetal than maternal circulation (P&lt;0.001). The fetal levels of these proteins were not correlated with maternal levels, nor with birth weight. Thus, during pregnancy, either osteoclastic or osteoblastic activity would appear to increase slightly, but the balance between bone formation and resorption is maintained. 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source J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles
subjects Biomarkers - blood
Bone and Bones - metabolism
Collagen - biosynthesis
Collagen - blood
Collagen - metabolism
Collagen Type I
Female
Fetal Blood - chemistry
Humans
Infant, Newborn
Maternal and fetal circulation
Osteocalcin
Osteocalcin - blood
Peptide Fragments - blood
Peptides - blood
Pregnancy
Procollagen - blood
Reference Values
Serum marker
Type I collagen
title Concentrations of Serum Markers of Type I Collagen Synthesis and Degradation and Serum Osteocalcin in Maternal and Umbilical Circulation
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