Inhibition of Lipid Peroxidation by Sesquiterpenoid in Heterotheca inuloides

A sesquiterpenoid, 7‐hydroxy‐3,4‐dihydrocadalin, isolated from a Mexican medicinal plant Heterotheca inuloides was evaluated as an antioxidant. This sesquiterpenoid inhibited mitochondrial and microsomal lipid peroxidation induced by Fe(III)‐ADP/NADH or Fe(III)‐ADP/NADPH. Furthermore, 7‐hydroxy‐3,4‐...

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Published in:Journal of pharmacy and pharmacology 1996-04, Vol.48 (4), p.441-443
Main Authors: HARAGUCHI, HIROYUKI, SAITO, TAKASHI, ISHIKAWA, HARUMI, SANCHEZ, YOLANDA, OGURA, TETSUYA, KUBO, ISAO
Format: Article
Language:English
Subjects:
Animals
Antioxidants - isolation & purification
Antioxidants - pharmacology
Biological and medical sciences
General pharmacology
In Vitro Techniques
Lipid Peroxidation - drug effects
Male
Medical sciences
Microsomes, Liver - drug effects
Microsomes, Liver - metabolism
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Rats
Rats, Wistar
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
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Summary:A sesquiterpenoid, 7‐hydroxy‐3,4‐dihydrocadalin, isolated from a Mexican medicinal plant Heterotheca inuloides was evaluated as an antioxidant. This sesquiterpenoid inhibited mitochondrial and microsomal lipid peroxidation induced by Fe(III)‐ADP/NADH or Fe(III)‐ADP/NADPH. Furthermore, 7‐hydroxy‐3,4‐dihydrocadalin protected red cells against oxidative haemolysis. This sesquiterpene was thus shown to be effective in protecting biological systems against oxidative stresses.
ISSN:0022-3573
2042-7158
DOI:10.1111/j.2042-7158.1996.tb05949.x