Restriction of Measles Virus Gene Expression in Measles Inclusion Body Encephalitis

Measles virus (MV) infection in brain tissue of a patient with measles inclusion body encephalitis was characterized by immunologic and biochemical techniques. Of the five major structural proteins of MV, only nucleocapsid (N) protein and phosphoprotein (P protein) were consistently detected in dise...

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Bibliographic Details
Published in:The Journal of infectious diseases 1988-07, Vol.158 (1), p.144-150
Main Authors: Baczko, Knut, Liebert, Uwe G., Cattaneo, Roberto, Billeter, Martin A., Roos, Raymond P., ter Meulen, Volker
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - microbiology
Encephalitis - complications
Encephalitis - microbiology
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes, Viral
Genetics
HeLa cells
Humans
Infant
Leukemia, Lymphoid - complications
Measles
Measles - complications
Measles - microbiology
Measles virus
Measles virus - genetics
Measles virus - isolation & purification
Messenger RNA
Microbiology
Monoclonal antibodies
Neurons
Original Articles
RNA
RNA, Messenger - analysis
RNA, Viral - analysis
Subacute sclerosing panencephalitis
Viral Proteins - analysis
Virology
Viruses
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Summary:Measles virus (MV) infection in brain tissue of a patient with measles inclusion body encephalitis was characterized by immunologic and biochemical techniques. Of the five major structural proteins of MV, only nucleocapsid (N) protein and phosphoprotein (P protein) were consistently detected in diseased brain areas. In contrast, hemagglutinin protein was seen only occasionally, and no membrane and fusion proteins were found in any of the sections studied. Messenger RNAs (mRNAs) specific for these five viral proteins were detected in all brain extracts examined; however, the mRNAs for the envelope proteins were clearly underrepresented in comparison with lytically infected cells. Only the mRNAs for N and P proteins appeared active in in vitro translations. These findings indicate quantitative differences in the pattern of mRNA expression in brain tissue and a restricted expression of MV envelope proteins in infected cells as observed in subacute sclerosing panencephalitis.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/158.1.144