Mechanism and management of ovulatory failure in women with polycystic ovary syndrome

Polycystic ovary syndrome is the most important cause of chronic anovulation. In women who fail to respond to clomiphene, low-dose FSH given in a step-wise fashion can induce normal follicular growth and ovulation. The failure of the action of endogenous FSH in these women may be related to reduced...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1988-05, Vol.3 (4), p.531-534
Main Authors: Franks, S., Mason, H.D., Polson, D.W., Winston, R.M.L., Margara, R., Reed, M.J.
Format: Article
Language:English
Subjects:
Androgens - blood
Anovulation - etiology
chronic anovulation
Clomiphene - therapeutic use
epidermal growth factor
Epidermal Growth Factor - analysis
Female
Follicle Stimulating Hormone - administration & dosage
Follicle Stimulating Hormone - blood
Follicle Stimulating Hormone - therapeutic use
FSH
Humans
Luteinizing Hormone - blood
Ovarian Follicle - drug effects
Ovarian Follicle - physiopathology
Ovulation Induction
polycystic ovary syndrome
Polycystic Ovary Syndrome - etiology
Pregnancy
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Summary:Polycystic ovary syndrome is the most important cause of chronic anovulation. In women who fail to respond to clomiphene, low-dose FSH given in a step-wise fashion can induce normal follicular growth and ovulation. The failure of the action of endogenous FSH in these women may be related to reduced biological activity of circulating FSH, but may also involve inhibition of its action at follicular level by polypeptide growth factors such as EGF.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a136739