Removal of autoantibodies in dilated cardiomyopathy by immunoadsorption

Immunoadsorption with Ig-Therasorb leads to a marked decrease in serum levels of immunoglobulins including of the agonist-like anti- β 1-adrenoceptor autoantibody found in the serum of patients with idiopathic dilated cardiomyopathy. The reduction in autoantibody levels was accompanied by an improve...

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Bibliographic Details
Published in:International journal of cardiology 1996-05, Vol.54 (2), p.191-195
Main Authors: Wallukat, G., Reinke, P., Dörffel, W.V., Luther, H.P., Bestvater, K., Felix, S.B., Baumann, G.
Format: Article
Language:English
Subjects:
Anti- β1-adrenoceptor autoantibody
Autoantibodies
Autoimmune diseases
Cardiomyopathies - immunology
Cardiomyopathies - therapy
Dilated cardiomyopathy
Humans
Immunoadsorption
Immunosorbent Techniques
Treatment Outcome
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Summary:Immunoadsorption with Ig-Therasorb leads to a marked decrease in serum levels of immunoglobulins including of the agonist-like anti- β 1-adrenoceptor autoantibody found in the serum of patients with idiopathic dilated cardiomyopathy. The reduction in autoantibody levels was accompanied by an improvement of heart function and a shift to a lower NYHA state. In this disease, as in a variety of other autoimmune disorders, apheresis with Ig-Therasorb led to a rapid improvement of the clinical status and could be used in end-stage dilated cardiomyopathy (with autoantibodies) as a bridge for transplantation.
ISSN:0167-5273
1874-1754
DOI:10.1016/0167-5273(96)02598-3