Evidence to suggest that the spontaneous release of acetylcholine from rat hippocampal tissue is carrier-mediated

The effect of L- and D-stereoisomers of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) on the spontaneous release of acetylcholine (ACh) from rat hippocampal tissue was studied. L-AH 5183 was approximately 100 times more potent than was D-AH 5183 in reducing spontaneous ACh release. Spontaneous ACh r...

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Bibliographic Details
Published in:Neurochemical research 1988-04, Vol.13 (4), p.325-328
Main Authors: IVY, M. T, CARROLL, P. T
Format: Article
Language:English
Subjects:
Acetylcholine - metabolism
Animals
Biological and medical sciences
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Fundamental and applied biological sciences. Psychology
Hippocampus - drug effects
Hippocampus - metabolism
In Vitro Techniques
Kinetics
Male
Neuromuscular Depolarizing Agents - pharmacology
Phencyclidine - analogs & derivatives
Phencyclidine - pharmacology
Piperidines
Rats
Rats, Inbred Strains
Reference Values
Stereoisomerism
Vertebrates: nervous system and sense organs
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Summary:The effect of L- and D-stereoisomers of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) on the spontaneous release of acetylcholine (ACh) from rat hippocampal tissue was studied. L-AH 5183 was approximately 100 times more potent than was D-AH 5183 in reducing spontaneous ACh release. Spontaneous ACh release was also temperature dependent. These results may suggest that the spontaneous release of ACh from brain tissue is carrier-mediated.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00972481