Acquired immune deficiency syndrome caused by hyperimmunity

Normal immunocytes including T and B cells are equilibrated by a reciprocal attacking mechanism called a network. Continuous disequilibrium of this network results in general immunodeficiency with oligo- and polyclonal hyperimmunity, for example, T-cell activation due to spontaneous reticuloendothel...

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Bibliographic Details
Published in:Medical hypotheses 1996-06, Vol.46 (6), p.489-498
Main Author: Chigira, M.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - therapy
AIDS/HIV
Animals
Apoptosis
Autoimmunity
B-Lymphocytes - immunology
Biological and medical sciences
Bone Marrow Transplantation
Graft vs Host Reaction
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Lymphatic Diseases - immunology
Medical sciences
Models, Immunological
Paraneoplastic Syndromes - immunology
T-Lymphocytes - immunology
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Summary:Normal immunocytes including T and B cells are equilibrated by a reciprocal attacking mechanism called a network. Continuous disequilibrium of this network results in general immunodeficiency with oligo- and polyclonal hyperimmunity, for example, T-cell activation due to spontaneous reticuloendotheliosis, paraneoplastic autoimmune syndromes, and human immunodeficiency virus infection. In these disorders, reciprocal self-reactivity, including autologous graft-versus-host reaction, plays a role in the immunodeficiency. A priori self-targeting immunity is a key mechanism to explain autoimmunity in the acquired immunodeficiency syndrome. In the treatment of the immunodeficiency due to hyperimmunity, I propose immunological suppression by agents and reconstitution of the network by bone-marrow transplantation.
ISSN:0306-9877
1532-2777
DOI:10.1016/S0306-9877(96)90118-8